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The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in adults with a body mass index (BMI) of greater than 27, given that they also have problems with weight-related health concerns such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder in addition to being an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that includes a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and still have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had an average weight loss of four.1% rather than participants who have been given placebos) during a 12- month period, while an outside study involving patients with type 2 diabetes had the average weight loss of 2% over treatment with placebo at one full year.
Using two separate drugs to lose weight can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you need to err along the side of caution and permit the FDA do its job and demand some investigation be done so your public understands the side effects and risks of the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on their medications.
Researchers found that participants using this drug to get a year, dropped excess weight within a month and have kept the weight off during the entire 56 weeks of the study. Contrave can be a combination of the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which are made up of several active ingredient, which can make them more efficient and safer.
Combo-pilling may be the newest fad or better yet the newest into the future under scrutiny and therefore it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular may be the fact that as of right now there aren't long term prescription weightloss pills that have been authorized by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be approved by the FDA.
Seizures are a side effect with Contrave and must not be taken in people with seizure disorders. The drug may also raise hypertension and heartrate, and must not be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.
The FDA also warned that Contrave can raise blood pressure level and heartrate and must stop used in patients with uncontrolled high hypertension, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation.
The course of recovery, even for those utilizing the medications, centers more on talk and less on pills because while drugs like acamprosate and naltrexone help change brain chemistry, they do not change minds. Once you adopt away the alcohol, sometimes with the successful utilization of prescribed medicine, the minds still need work. Alcoholics who slip in recovery and non-alcoholics drink for fundamentally the same reason: It relieves social/physical/emotional tension. With alcoholics however, their are programmed differently genetically and react to drinking with an increase of drinking. So counseling or even a 12-step meeting helps those abstinent keep from taking the first drink. Recovery has little or no to do with stopping the drinking and those successful in recovery admit they're success is founded on learning or relearning how to manage life's tensions.
