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  • The Food and Drug Administration, FDA, has approved the drug Vivitrol for your treatment of opioid dependence based on a news release by them on 10-12-2010.

    Using two separate drugs to lose weight naturally can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the those who go through it you should err along the side of caution and permit the FDA do its job and demand some study be done so that the public recognizes the side effects and dangers of the medications before we take them. Keep in mind that drug companies have been in business to generate income and that they would say anything to keep people on their medications.

    Researchers found out that participants using this drug for any year, lost excess weight within 4 weeks and have kept the load off through the 56 weeks from the study. Contrave is a combination with the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs that are made up of many active ingredient, which may make them more effective and safer.

    Combo-pilling will be the newest fad or even better the newest to come under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular will be the fact that since right now there are not any long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be authorized by the FDA.

    Seizures are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug can also raise blood pressure levels and heartbeat, and mustn't be used in people with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must stop used in patients with uncontrolled high blood pressure, along with by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients with a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients for the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.

    Suboxone contains two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but if the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone can be used correctly, the naloxone is destroyed within the liver right after uptake through the intestines and has no therapeutic effect. Buprenorphine could be the active substance; it can be absorbed beneath the tongue (and throughout the mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation in the event the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who have had gastric bypass, in which the first section of the intestine is bypassed and also the stomach contents empty in a more distal area of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy where the drug is taken up by the duodenum and transferred straight to the liver by the portal vein, where it really is quickly and completely destroyed. After gastric bypass naloxone can be adopted by servings of the intestine which are not served by the portal system, causing blood numbers of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.

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