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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in older adults with a body mass index (BMI) of greater than 27, so long as they also suffer from weight-related medical issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder in addition to being an aid to stop smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle including a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercising. Results from a medical trial that enrolled patients without diabetes established that patients had a typical weight loss of four.1% in contrast to participants who were given placebos) during a 12- month period, while a separate study involving patients with diabetes type 2 had an average weight loss of 2% over treatment with placebo at 12 months.
Using two separate drugs to lose weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err to the side of caution and permit the FDA do its job and demand some investigation be done in order that the public knows the side effects and dangers of the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on their medications.
Researchers found that participants using this drug for the year, lost weight within a month and have kept the weight off throughout the 56 weeks of the study. Contrave is a combination of the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which may make them more potent and safer.
Combo-pilling may be the newest fad or better yet the newest to come under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular will be the fact that since right now there aren't any long term prescription diet pills that have been approved by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA.
Seizures certainly are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug also can raise hypertension and heartbeat, and shouldn't be used in people who have a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.
The FDA also warned that Contrave can raise hypertension and heartrate and must not used in patients with uncontrolled high blood pressure, and also by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.
New UCLA study on smokers with mental, drug, and alcohol problems
