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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight-loss in addition to a reduced-calorie diet and physical exercise.
Using two separate drugs to shed pounds can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with fat loss and the people who go through it one should err assisting caution and allow FDA do its job and demand some research be done so the public understands the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies have been in business to generate income and that they would say almost anything to keep people on their medications.
Researchers found that participants taking this drug to get a year, lost weight within 4 weeks and have kept the body weight off throughout the 56 weeks in the study. Contrave can be a combination of the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which might be made up of more than one active ingredient, which may make them more potent and safer.
Combo-pilling will be the newest fad or better yet the newest into the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that at the time of right now there are no long term prescription slimming capsules that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be authorized by the FDA.
Seizures certainly are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug could also raise blood pressure and heart rate, and shouldn't be used in those with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.
The FDA also warned that Contrave can raise blood pressure and heart rate and must 't be used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients towards the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.
"There were no warning signs of depression or suicidal thoughts in trial participants," said Fujioka.
