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Evidence is increasing that all addiction without exception is related to issues with the brain's reward center, especially the mesolimbic system. This area of the problem regulates reward responses in establishing food and sex, plus nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both after they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to shed pounds can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the those who go through it one should err assisting caution and allow the FDA do its job and demand some investigation be done in order that the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say everything to keep people on their own medications.
Researchers discovered that participants using this drug for the year, dropped a few pounds within a month and have kept the body weight off through the entire 56 weeks from the study. Contrave is really a combination of the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which might be made up of several active ingredient, which might make them far better and safer.
Combo-pilling is the newest fad or in addition to this the newest to come under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular will be the fact that since right now there are no long term prescription slimming capsules that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be authorized by the FDA.
Seizures can be a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise blood pressure levels and pulse rate, and must not be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug.
The FDA also warned that Contrave can raise blood pressure levels and heart rate and must 't be used in patients with uncontrolled high blood pressure, and also by you are not heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients having a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients on the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.
The most common side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.
