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Evidence is increasing that addiction without exception is related to difficulty with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both once they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to shed pounds can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight reduction and the those who go through it one should err along the side of caution and allow the FDA do its job and demand some investigation be done so that the public understands the side effects and risks of the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say anything to keep people on their own medications.
Researchers found out that participants using this drug for a year, dropped a few pounds within 4 weeks and have kept the extra weight off throughout the 56 weeks from the study. Contrave is a combination with the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which are made up of more than one active ingredient, which can make them more effective and safer.
Combo-pilling may be the newest fad or also the newest in the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that since right now there aren't long term prescription slimming capsules that have been licensed by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be authorized by the FDA.
Seizures can be a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug may also raise blood pressure and heart rate, and mustn't be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.
The FDA also warned that Contrave can raise blood pressure and heart rate and must not used in patients with uncontrolled high blood pressure level, along with by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients having a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.
Other people who must avoid using Contrave are patients struggling with bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave should not be prescribed for women who are pregnant or attempting to become pregnant.
