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    The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not be used in patients with uncontrolled high hypertension, in addition to by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.

    From a psychiatric point of view, evidence implies that the ordinary neural mechanism for goal-directed behavior has become hijacked by the addiction, and malfunctions in such a way that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus as well as the person engages in a "goal-directed behavioral response" that generates a "natural high"(Bostwick & Bucci, 2008).

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