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Evidence is increasing that all addiction without exception is related to problems with the brain's reward center, particularly the mesolimbic system. This area of the problem regulates reward responses in acquiring food and sex, plus in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both once they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to lose weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with fat loss and the those who go through it one should err along the side of caution and allow the FDA do its job and demand some investigation be done in order that the public understands the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies are in business to generate income and that they would say everything to keep people on his or her medications.
Researchers found out that participants taking this drug to get a year, dropped a few pounds within four weeks and have kept the weight off through the entire 56 weeks in the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs that are made up of more than one active ingredient, which might make them more effective and safer.
Combo-pilling could be the newest fad or also the newest ahead under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular is the fact that by right now there aren't long term prescription weightloss pills that have been authorized by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be authorized by the FDA.
Seizures really are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug could also raise blood pressure and heart rate, and must not be used in those with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.
The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not be used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients which has a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking.
The most common effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.
