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Evidence is increasing that addiction without exception is related to difficulty with the brain's reward center, especially the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, plus in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both after they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to shed weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the those who go through it one should err to the side of caution and let the FDA do its job and demand some study be done so that the public knows the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies have been in business to generate income and that they would say anything to keep people on their own medications.
Researchers found that participants using this drug for any year, dropped a few pounds within one month and have kept the extra weight off throughout the 56 weeks from the study. Contrave can be a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs that are made up of several active ingredient, that might make them more potent and safer.
Combo-pilling will be the newest fad or even better the newest in the future under scrutiny and therefore it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular is the fact that since right now there are no long term prescription diet pills that have been approved by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be licensed by the FDA.
Seizures certainly are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug may also raise hypertension and heartrate, and shouldn't be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.
The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not used in patients with uncontrolled high hypertension, in addition to by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients towards the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.
The most common side effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.
