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    Researchers found out that participants using this drug to get a year, dropped excess weight within one month and have kept the weight off throughout the 56 weeks in the study. Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which might be made up of many active ingredient, which can make them more potent and safer.

    Combo-pilling may be the newest fad or in addition to this the newest to come under scrutiny and for that reason it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular may be the fact that as of right now there aren't long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be approved by the FDA.

    Seizures are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug also can raise hypertension and heartrate, and must not be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure and heartbeat and must 't be used in patients with uncontrolled high blood pressure, as well as by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

    "There were no signs and symptoms of depression or suicidal thoughts in trial participants," said Fujioka.

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