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    Researchers discovered that participants investing in this drug for the year, lost weight within one month and have kept the extra weight off during the entire 56 weeks of the study. Contrave is really a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which are made up of more than one active ingredient, which may make them more potent and safer.

    Combo-pilling is the newest fad or even better the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular is the fact that by right now there aren't long term prescription weightloss pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be approved by the FDA.

    Seizures are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug could also raise blood pressure levels and pulse rate, and mustn't be used in individuals with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure level and heartrate and must stop used in patients with uncontrolled high blood pressure levels, as well as by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

    Approving a drug with this many potentially lethal unwanted side effects is inconsistent while using mission statement of the FDA. The power from the drug manufacturing lobby is blatantly evident in the approval of numerous drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety inside the US.

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